|
KMID : 0361020200630110517
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
2020 Volume.63 No. 11 p.517 ~ p.522
|
|
|
Impact on Quality of Life after Treatment with Proton Pump Inhibitor in Laryngopharyngeal Reflux
|
|
Choi Hae-Won
Jun Hyun-Woong
Jeong Jin-Hyeok
Kim Moo-Keon
Tae Kyung
Ji Yong-Bae
|
|
|
Abstract
|
|
|
Background and Objectives: Several studies have assessed the impact of laryngopharyngealreflux disease (LPRD) on the health-related quality of life (HR-QoL), showing significantimpairment of HR-QoL. This study aims to assess the impact of proton pump inhibitor (PPI)treatment of LPRDs to enhance HR-QoL.
Subjects and Method: We prospectively collected data from LPRD patients from April2017 to July 2019. Patients who have reflux symptom index (RSI) of ≥13 or reflux findingscore (RFS) of ≥7 were enrolled in this study. We assessed HR-QoL using a questionnairewith EORTC QLQ-H&N35, -C30 on the first visit. Patients were treated with PPI (Ilaprazole20 mg/day) on their visits at 4, 8, and 12 weeks. RSI and RFS were measured at each visit andHR-QoL was reevaluated on the last visit.
Results: Ninety-five patients completed the 3-months follow-up and were enrolled in thisstudy. Female : male ratio was 71:24 and the mean age was 57.0±11.9 (27-80). The initial RSIand RFS were 16.3±8.8 and 12.6±2.9, respectively, but were changed to 11.1±9.7 and 9.7±2.6(p<0.001 in both) at 12 weeks after the treatment. Global health status/QoL, speech problem,dry mouth, and coughing were significantly improved.
Conclusion: PPI administration is effective in treating LPRD, where effects begin to appear at4 weeks after treatment. HR-QoL was also improved in patients who have RSI improvement.
|
|
|
KEYWORD
|
|
|
Laryngopharyngeal reflux, Laryngoscopy, Proton pump inhibitor, Quality of life
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|